Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer

The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages.

IL-10 is an important immunoregulatory factor. However, our understanding of IL-10 gene regulation remains very limited. In this study, following up on our previous novel finding that the protooncogene c-Maf of the basic leucine zipper family of transcription factors is expressed in monocytes and macrophages, we investigate the role of c-Maf in the transcriptional regulation of IL-10 and the un...

Expression in Macrophages Transcription Factor for IL-10 Gene The Protooncogene c-Maf Is an Essential

A critical regulatory role of leucin zipper transcription factor c-Maf in Th1-mediated experimental colitis.

In this study, we investigated the role of c-Maf, a transcription factor known to induce IL-4 production, in inflammatory bowel diseases and experimental colitis. Although Crohn's disease (CD) is associated with low IL-4 production by T-bet-expressing Th1 cells in the lamina propria, surprisingly a higher expression of c-Maf in these cells was found as compared with control patients. The releva...

c-Maf is essential for the F4/80 expression in macrophages in vivo.

c-Maf, which is one of the large Maf transcription factors, can bind to Maf recognition element (MARE) and activates transcription of target genes. Although c-Maf is expressed in macrophages and directly regulates the expression of interleukin-10, detailed information regarding its function in the null mutant phenotype of tissue macrophages remain unknown. In this study, we demonstrated that c-...

c-Maf Transcription Factor Regulates ADAMTS-12 Expression in Human Chondrogenic Cells

OBJECTIVE ADAMTS (a disintegrin and metalloproteinase with thrombospondin type-1 motif) zinc metalloproteinases are important during the synthesis and breakdown of cartilage extracellular matrix. ADAMTS-12 is up-regulated during in vitro chondrogenesis and embryonic limb development; however, the regulation of ADAMTS-12 expression in cartilage remains unknown. The transcription factor c-Maf is ...